{"id":6538,"date":"2017-09-04T17:22:14","date_gmt":"2017-09-04T08:22:14","guid":{"rendered":"http:\/\/sip-vc.com\/?p=6538"},"modified":"2018-09-30T16:24:31","modified_gmt":"2018-09-30T07:24:31","slug":"%ef%be%92%ef%be%83%ef%be%9e%ef%bd%a8%ef%bd%b6%ef%be%99%ef%be%83%ef%bd%b8%ef%be%89%ef%be%9b%ef%bd%bc%ef%be%9e%ef%bd%b0%e3%83%bb%ef%bd%b1%ef%be%84%ef%be%9e%ef%be%8a%ef%be%9e%ef%bd%b2%ef%bd%bb%ef%be%9e","status":"publish","type":"post","link":"https:\/\/sip-vc.com\/?p=6538","title":{"rendered":"\uff92\uff83\uff9e\uff68\uff76\uff99\uff83\uff78\uff89\uff9b\uff7c\uff9e\uff70\u30fb\uff71\uff84\uff9e\uff8a\uff9e\uff72\uff7b\uff9e\uff70\u3000\u82b1\u4e95\u3000\u9806\u4e00"},"content":{"rendered":"

\"hanai\"<\/p>\n

\u30e1\u30c7\u30a3\u30ab\u30eb\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u30fb\u30a2\u30c9\u30d0\u30a4\u30b6\u30fc\u3000\u82b1\u4e95 \u9806\u4e00<\/p>\n

\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8\u3000
\n\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u30fb\u30b8\u30a7\u30cd\u30e9\u30eb\u30fb\u30db\u30b9\u30d4\u30bf\u30eb\u3000MGH\u764c\u30bb\u30f3\u30bf\u30fc<\/p>\n

1962\u5e74\u751f\u307e\u308c\u30021988\u5e74\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u533b\u5b66\u79d1\u5352\u696d\u5f8c\u3001\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u4ed8\u5c5e\u75c5\u9662\u5185\u79d1\u30fb\u653e\u5c04\u7dda\u79d1\u3001\u516c\u7acb\u662d\u548c\u75c5\u9662\u6551\u6025\u533b\u5b66\u79d1\u3067\u3001\u5185\u79d1\u81e8\u5e8a\u30fb\u753b\u50cf\u8a3a\u65ad\u30fb\u6551\u6025\u533b\u7642\u3092\u7814\u4fee\u533b\u3068\u3057\u3066\u7814\u947d\u3057\u305f\u5f8c\u30011991\u5e74\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u4ed8\u5c5e\u75c5\u9662\u7b2c\u4e00\u5185\u79d1\u3078\u5165\u5c40\u3002\u9ed2\u5ddd\u6e05\u6559\u6388\u6307\u5c0e\u306e\u4e0b\u3001\u814e\u81d3\u5185\u79d1\u3092\u5c02\u653b\u3057\u3001\u6771\u5927\u75c5\u9662\u3067\u306e\u81e8\u5e8a\u696d\u52d9\uff08\u75c5\u68df\/\u5916\u6765\uff09\u30fb\u81e8\u5e8a\u6559\u80b2\u30fb\u81e8\u5e8a\u7814\u7a76\u306b\u643a\u308f\u308a\u5185\u79d1\u81e8\u5e8a\u5168\u822c\u306b\u5e45\u5e83\u304f\u5c02\u5ff5\u3059\u308b\u30021994\u5e74\u6771\u5927\u7b2c\u4e00\u5185\u79d1\u52a9\u624b\u30021996\u5e74\u9ed2\u5ddd\u6559\u6388\u306e\u7d39\u4ecb\u3067\u764c\u7814\u7a76\u4f1a\u764c\u7814\u7a76\u6240\u751f\u5316\u5b66\u90e8\u306e\u5631\u8a17\u7814\u7a76\u54e1\u3068\u3057\u3066\u5bae\u5712\u6d69\u5e73\u90e8\u9577\uff08\u73fe\u6771\u5927\u533b\u5b66\u90e8\u9577\uff09\u306e\u4e0b\u3067\u57fa\u790e\u7814\u7a76\u3092\u59cb\u3081\u308b\u3002\u764c\u3084\u7d44\u7e54\u7e4a\u7dad\u5316\u306a\u3069\u591a\u304f\u306e\u75c5\u614b\u306b\u6df1\u304f\u95a2\u308f\u308bTGF-\u03b2\u60c5\u5831\u4f1d\u9054\u7cfb\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u56e0\u5b50\u306e\u540c\u5b9a\u3001TGF-\u03b2\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u643a\u308f\u308a\u3001\u4e16\u754c\u30ec\u30d9\u30eb\u306e\u7814\u7a76\u306b\u89e6\u767a\u3055\u308c\u308b\u4e2d\u3067\u3001\u7d30\u80de\u751f\u7269\u5b66\u30fb\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7814\u7a76\u306e\u57fa\u790e\u3092\u5b66\u3073\u3001Nature, EMBO J, PNAS \u7b49\u4e16\u754c\u306e\u4e00\u6d41\u8a8c\u3067\u306e\u8ad6\u6587\u767a\u8868\u306b\u81f3\u308b\u3002<\/p>\n

\u9ed2\u5ddd\u6559\u6388\u30fb\u5bae\u5712\u6559\u6388\u306e\u7d39\u4ecb\u3067\u30011999\u5e74\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8 Beth Israel Deaconess Medical Center (BIDMC) \u814e\u81d3\u5185\u79d1 (Division of Nephrology) \u3078Vikas P. Sukhatme\u6559\u6388 (\u73feChief of the Academic Officers: CAO)\u6307\u5c0e\u306e\u4e0b\u3067\u7559\u5b66\u30022000\u5e74\u533b\u5b66\u535a\u58eb\u5b66\u4f4d\u53d6\u5f97\u3002\u8840\u7ba1\u751f\u7269\u5b66\u306e\u7956\u3068\u8a00\u308f\u308c\u308b\u6545Judah Folkman\u6559\u6388\uff08Boston\u5c0f\u5150\u75c5\u9662\uff09\u306b\u5b66\u751f\u6642\u4ee3\u306b\u85ab\u9676\u3092\u53d7\u3051\u305fSukhatme\u6559\u6388\u304cBIDMC\u306e\u814e\u81d3\u5185\u79d1\u4e3b\u4efb\u6559\u6388\u3068\u3057\u3066\u816b\u760d\u8840\u7ba1\u65b0\u751f\u306e\u7814\u7a76\u3092\u59cb\u3081\u305f\u7814\u7a76\u5ba4\u306b\u52a0\u308f\u308a\u3001Folkman\u6559\u6388\u304c\u767a\u898b\u3057\u305f\u751f\u4f53\u5185\u3067\u751f\u6210\u3055\u308c\u308bendostatin\uff08\u8840\u7ba1\u65b0\u751f\u963b\u5bb3\u7269\u8cea\uff09\u306e\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3092\u8ab2\u984c\u3068\u3057\u3066\u4e0e\u3048\u3089\u308c\u305f\u3002<\/p>\n

\u540c\u50da\u306e Ananth Karumanchi\uff08\u73fe\u30fb\u814e\u81d3\u5185\u79d1\u6559\u6388\uff09\u3068 endostatin \u53d7\u5bb9\u4f53\u306e\u540c\u5b9a\u3092\u884c\u3044\u3001\u4e00\u65b9\u3067\u767a\u751f\u5b66\u8005 Sergei Sokol \u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u3067 Xenopus embryo \u306e\u8868\u73fe\u7cfb\u3092\u7528\u3044\u3066\u3001ensostatin \u304c\u5e79\u7d30\u80de\u3084\u7d30\u80de\u306e\u5206\u5316\u306b\u91cd\u8981\u306a Wnt signaling \u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057Nature\u8a8c\u3084Folkman\u6559\u6388\u306e\u8b1b\u6f14\u3067\u7279\u96c6\u3055\u308c\u308b (JCB, JBC)\u3002\u7814\u7a76\u6240\u30b9\u30bf\u30c3\u30d5\u3068\u3057\u3066\u63a1\u7528\u3055\u308c\u3001Leonard Zon \u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u3067zebrafish\u306evisualize\u3055\u308c\u305f\u7cfb\u3067\u8840\u7ba1\u65b0\u751f\u7814\u7a76\u3092\u7d9a\u3051\u308b\u4e2d\u3067\u3001clinical-oriented \u306a\u7814\u7a76\u306e\u65b9\u5411\u6027\u3068\u75c5\u614b\u89e3\u660e\u306e\u57fa\u790e\u3092\u5b66\u3076\u3002\u3053\u306e\u904e\u7a0b\u3067\u3001\u4e0a\u76ae\u7d30\u80de\u7cfb\u306b\u5099\u308f\u308b\u5206\u5316\u30b7\u30b9\u30c6\u30e0 epithelial mesenchymal transition (EMT)\u304c\u3001\u8907\u6570\u306e\u75c5\u614b\u306b\u5171\u901a\u3057\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u6c17\u3065\u304d\u3001\u4ee5\u964d\u3001EMT\u306e\u95a2\u308f\u308b\u69d8\u3005\u306a\u75c5\u614b\u2014-\u8840\u7ba1\u65b0\u751f (Nat Medicine, JCB)\u3001\u7d44\u7e54\u7e4a\u7dad\u5316 (Nat Medicine)\u3001\u816b\u760d\u8ee2\u79fb (JBC, Cancer Res)\u3001\u5275\u50b7\u6cbb\u7652\u3001\u52d5\u8108\u786c\u5316\u3001\u8840\u7ba1\u77f3\u7070\u5316\u3001\u8001\u5316 (Aging)\u3001\u764c\u5e79\u7d30\u80de(Cell Death Diff)\u3001\u8102\u8cea\u4ee3\u8b1d\u3001\u7d44\u7e54\u518d\u751f\u3001\u85ac\u5264\u6027\u7b4b\u969c\u5bb3 (JCI)\u2014-\u306e\u89e3\u660e\u306b\u53d6\u308a\u7d44\u307f\u3001\u305d\u306e\u904e\u7a0b\u3067Interdisciplinary Medicine and Biotechnology (IMBIO) \u3068\u3044\u3046Division\u306e\u5275\u8a2d\u306b\u643a\u308f\u308a\u3001\u73fe\u5728\u3001\u814e\u81d3\u5185\u79d1\u3068\u517c\u4efb\u3067\u4e21division\u306efaculty \u3092\u52d9\u3081\u308b\u3002<\/p>\n

\u793e\u4f1a\u7684\u306a\u30a4\u30f3\u30d1\u30af\u30c8\u306b\u81f3\u3063\u305f\u4ed5\u4e8b\u3068\u3057\u3066\u306f\u3001\u4ee5\u4e0b\u306e\u3082\u306e\u304c\u3042\u308b\u3002<\/p>\n

\uff11\uff09preeclampsia\uff08\u5b50\u7647\uff09\u306e\u75c5\u614b\u89e3\u660e\u3068\u8a3a\u65ad\uff0f\u4e88\u9632\u6cd5\u306e\u69cb\u7bc9<\/p>\n

\u540c\u50da\u306eAnanth Karumanchi\u3068\u3068\u3082\u306b\u9032\u3081 (Nature Medicine, NEJM)\u3001\u591a\u304f\u306e\u88fd\u85ac\u4f01\u696d\u3068\u5171\u5f79\u3057\u3001\u30a2\u30d5\u30ea\u30ab\u3092\u4e2d\u5fc3\u306b\u4e16\u754c\u306e\u5468\u7523\u671f\u533b\u7642\u306b\u304a\u3051\u308b\u6b7b\u4ea1\u7387\u306e\u4f4e\u4e0b\u306b\u8ca2\u732e\u3057WHO\u304b\u3089\u8868\u5f70\u3002<\/p>\n

\uff12\uff09\u6297\u9ad8\u8102\u8840\u75c7\u85ac\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u7b4b\u969c\u5bb3\u306e\u75c5\u614b\u89e3\u660e<\/p>\n

zebrafish\u3092\u7528\u3044\u305f\u30b7\u30b9\u30c6\u30e0\u3067\u89e3\u660e\u3057(JCI) \u3001\u751f\u4f53\u306b\u304a\u3051\u308b\u7b4b\u969c\u5bb3\u3092\u53ef\u8996\u5316\u3057\u3066\u75c5\u614b\u89e3\u660e\u306b\u8ca2\u732e\u3057\u305f\u3053\u3068\u3067\u6ce8\u76ee\u3055\u308c\u308b\u3002Harvard Focus\u30fb\u30a2\u30e1\u30ea\u30ab\u4e00\u822c\u8a8c\u306b\u3066\u7279\u96c6\u3002<\/p>\n

\uff13\uff09\u764c\u6cbb\u7642\u3068\u3057\u3066\u6297\u764c\u5264\u3092\u4f7f\u7528\u305b\u305a\u3001\u30b9\u30bf\u30c1\u30f3\u3068ACLY \u62ee\u6297\u85ac\u306e\u4f75\u7528\u3068\u3044\u3046\u3001\u4ee3\u8b1d\u62ee\u6297\u85ac\u3060\u3051\u3067\u6709\u52b9\u306a\u6297\u816b\u760d\u52b9\u679c\u3092\u793a\u3057\u305fLewis C. Cantley\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76 (JCP, Cell Death Diff)<\/p>\n

\u764c\u907a\u4f1d\u5b50\u304c\u4f5c\u7528\u3059\u308b\u7d50\u679c\u3067\u3042\u308b\u3001\u764c\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u6cbb\u7642\u52b9\u679c\u3092\u4e0a\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5177\u4f53\u4f8b\u3092\u793a\u3059\u3053\u3068\u306b\u6210\u529f\u3057\u3001\u73fe\u5728\u81e8\u5e8a\u7684\u306a\u5fdc\u7528\u3092\u542b\u3081\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002
\n\uff14\uff09\u4ee3\u8b1d\u9175\u7d20LDH\u6291\u5236\u304c\u3001\u764c\u5e79\u7d30\u80de\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u7e4b\u304c\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305fPier Paolo Pandolfi\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76(Cell Metabolism)<\/p>\n

\u4ee3\u8b1d\u7684\u306a\u5909\u5316\u304c\u3001\u764c\u7d30\u80de\u306e\u5206\u5316\u3092\u4fc3\u3057\u3001\u764c\u5e79\u7d30\u80de\u306e\u8a98\u5c0e\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u764c\u7d30\u80de\u306b\u81f3\u308b\u764c\u8a98\u5c0e\u30b7\u30b0\u30ca\u30eb\u3092\u6291\u5236\u3059\u308b\u5f93\u6765\u306e\u764c\u6cbb\u7642\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u764c\u907a\u4f1d\u5b50\u304c\u4f5c\u7528\u3059\u308b\u7d50\u679c\uff08\u4ee3\u8b1d\u30fb\u514d\u75ab\uff09\u306b\u6ce8\u76ee\u3057\u3001\u305d\u306e\u7d50\u679c\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u3067\u3001\u6709\u76ca\u306a\u6cbb\u7642\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u306b\u6210\u529f\u3002<\/p>\n

5) \u6162\u6027\u814e\u4e0d\u5168\u306bEMT\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u521d\u3081\u3066\u793a\u3059\uff08Nat Medicine)<\/p>\n

\u3053\u306e\u75c5\u614b\u306e\u6709\u7121\u306b\u95a2\u3057\u3066\u306f\u75c5\u7406\u5b66\u8005\u3068\u306e\u9577\u3044\u8ad6\u4e89\u304c\u7d9a\u3044\u305f\u304c\u3001\u767a\u751f\u5b66\u8005\u304b\u3089\u306e\u6307\u6458\u3001\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3067\u306eevidence\u306a\u3069\u304b\u3089\u3001EMT\u306e\u4e9c\u578b\u3068\u3057\u3066partial EMT\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u508d\u8a3c\u3068\u3057\u3066\u793a\u3055\u308c\u305f\u3002\u6162\u6027\u306e\u814e\u81d3\u75be\u60a3\u3078\u306e\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u521d\u3081\u3066\u63d0\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n

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